The FY2023-1 Small Business Innovation Research Contract (SBIR) Program solicitation has been posted!


“The National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) invite small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation. Firms with the capability to conduct research and development (R&D) in any of the health-related topic areas described in Section 12.0, and to commercialize the results of that R&D, are encouraged to participate.”

Please see link above for specific solicitations.

There is a webinar scheduled for Sept 27th, at 1pm ET hosted by NIH. Register here.

Contract funding is very different from grant funding, and a project needs to be a very (very) good fit to pursue this mechanism. NIAID offers a useful resource to compare differences between grants and contracts – although written specifically for NIAID, these guidelines generally apply across NIH contracts.

Wondering if your company could win non-dilutive funding through an SBIR contract? Have questions about understanding the solicitation details? Reach out today and we will connect you with one of our experts!

  • FY2023 NIH SBIR Contract Topics: 


    (A Phase I proposal and a Phase II proposal submitted simultaneously)


    (Includes only a Phase II Proposal)

    NIH/NCATS 024 Yes No No Small Manufacturing Systems to Produce Research Grade Pharmaceutical Intermediates

    NIH/NCI 455

    Yes Yes Yes Point-of-Care Detection of Prostate Specific Antigen

    NIH/NCI 456

    No Yes Yes

    Rapid and Affordable Point-of-Care HPV Diagnostics for Cervical Cancer Control

    NIH/NCI 457

    Yes Yes No

    Technologies for Detecting Tumor-Derived Cell Clusters

    NIH/NCI 458

    Yes No No

    Microbiome-Based Tests for Cancer Research, Diagnosis, Prognosis and/or Patient Management

    NIH/NCI 459

    Yes Yes No

    Automated Software for Point-of-Care Testing to Identify Cancer-Associated Malnutrition

    NIH/NCI 460

    Yes No No

    Evaluation Datasets as Medical Device Development Tools for Testing Cancer Technologies

    NIH/NCI 461

    Yes Yes Yes

    Ultra-Fast Dose Rate (FLASH) Radiation Detectors and Safety Systems for Cancer Treatment

    NIH/NCI 462

    Yes Yes Yes

    Organ-on-Chip for Preclinical and Translational Radiobiological Studies

    NIH/NCI 463

    Yes Yes Yes

    Translation of Novel Cancer-specific Imaging Agents and Techniques to Mediate Successful Image-guided Cancer Interventions

    NIH/NCI 464

    Yes Yes Yes

    Cloud-Based Multimodal Data Analysis Software for the Cancer Research Data Commons

    NIH/NCI 465

    Yes Yes Yes

    Cancer Prevention and Treatment Clinical Trials Tools for Recruitment and Retention of Diverse Populations

    NIH/NIA 010

    Yes Yes Yes

    Technology to facilitate characterization of the exosome in under –resourced populations for AD/ADRD Studies

    NIH/NIAID 124

    Yes Yes No

    Development of Next-Generation Devices and Materials-Based Platforms for the Administration of HIV-1 Broadly Neutralizing Antibodies

    NIH/NIAID 125

    Yes Yes No

    Development of Long-Acting Treatments for HCV Cure

    NIH/NIAID 126

    Yes Yes No

    Rapid Diagnostic Assays for Self-Monitoring of Acute or Rebound HIV-1 Infection

    NIH/NIAID 127

    Yes Yes No

    Multiplexed Patient Administered Diagnostics for Hepatitis B, Hepatitis C, and HIV

    NIH/NIAID 128

    Yes Yes Yes

    Adjuvant Development for Vaccines for Infectious and Immune-Mediated Diseases

    NIH/NIAID 129

    Yes Yes Yes

    Reagents for Immunologic Analysis of Non- mammalian and Underrepresented Mammalian Models

    NIH/NIAID 130

    Yes Yes Yes

    Adjuvant Discovery and Down-Selection for Vaccines against Infectious and Immune-Mediated Diseases

    NIH/NIAID 131

    Yes Yes No

    Development of Bacteriophage for Treatment of Mycobacterial Infections

    NIH/NIAID 132

    Yes Yes No

    Novel Diagnostic Biomarker Discovery and Validation for Malaria and Select Neglected Tropical Diseases (NTDs)

    NIH/NIAID 133

    Yes Yes No

    Development of a Serological Test for Herpes Simplex Types 1 and 2 Infections

    NIH/NIAID 134

    Yes Yes Yes

    Alternatives to Benzathine Penicillin for Treatment of Syphilis

    NIH/NIAID 135

    Yes Yes Yes

    Software or Web Services to Automate Metadata Enrichment and Standardization for Data on Infectious and Immune – Mediated Diseases

    NIH/NIAID 136

    Yes Yes Yes

    Software or Web Services to Re-Represent Existing Scientific Data and Knowledge into a Knowledge Graph Format

    NIH/NHLBI 115

    Yes Yes Yes

    Clinical Instrument for Para-Hydrogen (pH2) Based Signal Amplification by Reversible Exchange (SABRE) for Hyperpolarizing 13C-Pyruvate and Other Probes for MRI Imaging

    NIH/NIAID 108 Yes Yes No Development of Rapid POC Diagnostics for Treponema pallidum

    NIH/NIMH 001

    Yes No No

    Point-of-Care HIV Viral Load and Drug Adherence Assays

    NIH/NIMH 002

    Yes No No

    Development of novel In-vitro and In-vivo Models to support NeuroHIV Research

    CDC/NCEZID 031

    Yes No No

    Development of SHERLOCK Assay for Detection of High Threat Orthopoxviruses


    Yes No No

    Software Solutions: Bridging the Gap between Public Health and Pharmacies


    Yes No No

    EHR Algorithm to Identify Persons with HIV Not in Care


    Yes No No

    Device for point-of-care nucleic acid purification and detection of HCV

    CDC/NCIRD 036

    Yes No No

    Improved Diagnostic Assays for Measles, Mumps, Rubella, and Varicella

    CDC/NCIRD 037

    Yes No No

    Rapid Diagnostic Tests for Measles, Mumps, Rubella, and Varicella

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